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The low CSF-to-plasma ratio of compound D and the absence of compound Q in CSF may suggest the need for Phase Ib dosing studies to explore novel strategies for increasing Q bioavailability and D levels in the CNS

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Afterward, the potential interactions of these peptides with key sites of pancreatic lipase (leading to the inhibition of the enzyme) were predicted via molecular docking (Wang, Ai, et al., 2022)